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Analysis of prognostic factors in ewing sarcoma family of tumors
- Source :
- Cancer. 110:375-384
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- BACKGROUND. Advances in systemic and local therapies have improved outcomes for patients with the Ewing sarcoma family of tumors (ESFT). As new treatments are developed, a critical review of data from past treatment eras is needed to identify clinically relevant risk groups. METHODS. The authors reviewed the records of 220 patients with ESFT who were treated on protocols at St. Jude Children’s Research Hospital from 1979 to 2004. Two treatment eras were defined. Factors predictive of outcome were analyzed to identify distinct risk groups. RESULTS. The median age at diagnosis was 13.7 years (range, 1.1–25.2 years). Metastatic disease was associated with tumors measuring [ 8c m (P 5 .002) and axial location (P 5 .014). The 5-year overall survival (OS) estimate (63.5% � 3.5%) did not appear to differ by protocol. Tumor stage and size were found to be the only independent predictors of outcome. Treatment era and type of local control therapy were found to influence the outcome of patients with localized disease. Four risk groups were defined: favorable risk (age
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Adolescent
Sarcoma, Ewing
Internal medicine
Epidemiology
medicine
Humans
Risk factor
Child
Retrospective Studies
Medical Audit
business.industry
Incidence (epidemiology)
Infant
Cancer
Neoplasms, Second Primary
Retrospective cohort study
Prognosis
medicine.disease
Pediatric cancer
Surgery
Treatment Outcome
Child, Preschool
Localized disease
Female
Sarcoma
business
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....ec6bc781b1c1dbf7733d8d760de8297d