Back to Search
Start Over
Development and characterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents
Development and characterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents
- Source :
- Asian Journal of Pharmaceutical Sciences, Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 4, Pp 335-343 (2017)
- Publication Year :
- 2016
-
Abstract
- Graphical Abstract Unlabelled image<br />Solid dispersions of nifedipine (NDP), a poorly water-soluble drug, and amino methacrylate copolymer (AMCP) with aid of adsorbent, that is, fumed silica, talcum, calcium carbonate, titanium dioxide, and mesoporous silica from rice husks (SRH), were prepared by solvent method. The physicochemical properties of solid dispersions, compared to their physical mixtures, were determined using powder X-ray diffractometry (PXRD) and differential scanning calorimetry (DSC). The surface morphology of the prepared solid dispersions was examined by scanning electron microscopy (SEM). The dissolution of NDP from solid dispersions was compared to NDP powders. The effect of adsorbent type on NDP dissolution was also examined. The dissolution of NDP increased with the ratio of NDP:AMCP:adsorbent of 1:4:1 when compared to the other formulations. As indicated from PXRD patterns, DSC thermograms and SEM images, NDP was molecularly dispersed within polymer carrier or in an amorphous form, which confirmed the better dissolution of solid dispersions. Solid dispersions containing SRH provided the highest NDP dissolution, due to a porous nature of SRH, allowing dissolved drug to fill in the pores and consequently dissolve in the medium. The results suggested that solid dispersions containing adsorbents (SRH in particular) demonstrated improved dissolution of poorly water-soluble drug when compared to NDP powder.
- Subjects :
- Materials science
Nifedipine
Solid dispersion
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION
Adsorbent
Pharmaceutical Science
02 engineering and technology
Poorly water-soluble drug
030226 pharmacology & pharmacy
ComputingMethodologies_ARTIFICIALINTELLIGENCE
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Adsorption
Differential scanning calorimetry
Organic chemistry
Original Research Article
Dissolution
Fumed silica
ComputingMethodologies_COMPUTERGRAPHICS
Pharmacology
lcsh:RM1-950
Mesoporous silica from rice husks
Mesoporous silica
021001 nanoscience & nanotechnology
Amorphous solid
Amino methacrylate copolymer
Solvent
lcsh:Therapeutics. Pharmacology
ComputingMethodologies_PATTERNRECOGNITION
Chemical engineering
chemistry
Titanium dioxide
0210 nano-technology
Subjects
Details
- ISSN :
- 2221285X
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Asian journal of pharmaceutical sciences
- Accession number :
- edsair.doi.dedup.....ec53355aab34d08202ed7dd068364fa9