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Synthesis of Di-Substituted Alkynes via Palladium-Catalyzed Decarboxylative Coupling and C-H Activation
- Source :
- CHEMISTRYSELECT
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- A straightforward methodology for the decarboxylative cross-coupling of aryl bromides and phenylpropiolic acid using a Pd(II)-NHC catalyst has been developed. Various aryl bromides have been successfully transformed into the corresponding di-substituted alkynes using environmentally benign conditions (weak base and ethanol as solvent). This efficient catalytic system also proved useful for the copper-free Sonogashira coupling of aryl and alkenyl bromides with various terminal alkynes. The synthetic utility of these methodologies was highlighted in the synthesis of a polyaromatic compound and various fluoroenynes.
- Subjects :
- Internal alkyne
NHC
Decarboxylation
SUZUKI-MIYAURA
chemistry.chemical_element
FREE SONOGASHIRA REACTION
Catalysis
CARBON
Coupling
PRE-CATALYST
HETEROCYCLIC CARBENE
Polymer chemistry
ARYL CHLORIDES
CARBOXYLIC-ACIDS
Chemistry
COPPER-FREE
General Chemistry
DIARYLALKYNES
Coupling (electronics)
Aryl bromide
Fluoroenyne
COMPLEXES
Palladium
Subjects
Details
- ISSN :
- 23656549
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- ChemistrySelect
- Accession number :
- edsair.doi.dedup.....ec3fd74025c4fce6179db666580a69fe