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The main obstacle to a malaria vaccine: the malaria parasite
- Source :
- Vaccine. 6:104-106
- Publication Year :
- 1988
- Publisher :
- Elsevier BV, 1988.
-
Abstract
- The challenge to development of a malaria vaccine will be the variability of the sequences of target antigens. We discuss the variability in the T cell epitopes on the circumsporozoite protein of Plasmodium falciparum and the rapid selection of mutants after immunization with a protein from the asexual erythrocytic stage of P. knowlesi.
- Subjects :
- Plasmodium
T-Lymphocytes
Plasmodium falciparum
Protozoan Proteins
Antigens, Protozoan
Antigen
parasitic diseases
medicine
Antigenic variation
Animals
Vaccines
General Veterinary
General Immunology and Microbiology
biology
Malaria vaccine
Public Health, Environmental and Occupational Health
biology.organism_classification
medicine.disease
Antigenic Variation
Virology
Circumsporozoite protein
Infectious Diseases
Immunization
Antigens, Surface
Mutation
Immunology
Molecular Medicine
Protozoa
Malaria
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....ec3c962e2dbe19cb68212ee0745307e8