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Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder
- Source :
- British journal of haematology. 120(4)
- Publication Year :
- 2003
-
Abstract
- Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.
- Subjects :
- Pathology
medicine.medical_specialty
Malignant Mastocytosis
CD2 Antigens
Bone Marrow Cells
Disease
Pathogenesis
Mast (sailing)
Mastocytosis, Systemic
Antigens, Neoplasm
Biomarkers, Tumor
Medicine
Humans
In patient
IL-2 receptor
Mast Cells
Prospective Studies
business.industry
Receptors, Interleukin-2
Hematology
Mast cell
Hematologic Diseases
medicine.anatomical_structure
Immunology
Bone marrow
business
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 120
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- British journal of haematology
- Accession number :
- edsair.doi.dedup.....ec359ce8b8c2f598efd949d0cc85c4c0