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Notoginsenoside R1 for Organs Ischemia/Reperfusion Injury: A Preclinical Systematic Review
- Source :
- Frontiers in Pharmacology, Vol 10 (2019), Frontiers in Pharmacology
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Notoginsenoside R1 (NGR1) exerts pharmacological actions for a variety of diseases such as myocardial infarction, ischemic stroke, acute renal injury, and intestinal injury. Here, we conducted a preclinical systematic review of NGR1 for ischemia reperfusion (I/R) injury. Eight databases were searched from their inception to February 23rd, 2019; Review Manager 5.3 was applied for data analysis. CAMARADES 10-item checklist and cell 10-item checklist were used to evaluate the methodological quality. Twenty-five studies with 304 animals and 124 cells were selected. Scores of the risk of bias in animal studies ranged from 3 to 8, and the cell studies ranged from 3 to 5. NGR1 had significant effects on decreasing myocardial infarct size in myocardial I/R injury, decreasing cerebral infarction volume and neurologic deficit score in cerebral I/R injury, decreasing serum creatinine in renal I/R injury, and decreasing Park/Chiu score in intestinal I/R injury compared with controls (all P < 0.05 or P < 0.01). The multiple organ protection of NGR1 after I/R injury is mainly through the mechanisms of antioxidant, anti-apoptosis, and anti-inflammatory, promoting angiogenesis and improving energy metabolism. The findings showed the organ protection effect of NGR1 after I/R injury, and NGR1 can potentially become a novel drug candidate for ischemic diseases. Further translation studies are needed.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Ischemia
ischemia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
organ
Pharmacology (medical)
Myocardial infarction
Stroke
Pharmacology
preclinical systematic review
Creatinine
Cerebral infarction
business.industry
lcsh:RM1-950
notoginsenoside R1
medicine.disease
reperfusion
meta-analysis
030104 developmental biology
lcsh:Therapeutics. Pharmacology
chemistry
030220 oncology & carcinogenesis
Meta-analysis
Cardiology
Systematic Review
Animal studies
business
Reperfusion injury
Subjects
Details
- Language :
- English
- ISSN :
- 16639812
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology
- Accession number :
- edsair.doi.dedup.....ec332f32bd12a719fa07c18a19fe1f21