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Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. We carried out ReHo analysis to assess differences in neural activity between the 2 groups, and receiver operating characteristic curve (ROC) analysis was performed to evaluate the performance of ReHo values of specific brain areas in distinguishing DE patients from HCs. The relationship between average ReHo values and clinical characteristics was assessed by correlation analysis. ReHo values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in DE patients compared to HCs. The ROC analysis showed that ReHo value had high accuracy in distinguishing between DE patients and HCs (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Science
Inferior frontal gyrus
Models, Biological
behavioral disciplines and activities
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Image Processing, Computer-Assisted
medicine
Humans
Middle frontal gyrus
Author Correction
Aged
Brain Mapping
Multidisciplinary
Resting state fMRI
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Diagnostic markers
Middle Aged
Frontal gyrus
Magnetic Resonance Imaging
Treatment efficacy
Frontal Lobe
ROC Curve
Superior frontal gyrus
030221 ophthalmology & optometry
Cardiology
Medicine
Dry Eye Syndromes
Female
Disease Susceptibility
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....ec2f444b2da8dd0bf8fbe33660867e84