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Predissection-derived geometric and distensibility indices reveal increased peak longitudinal stress and stiffness in patients sustaining acute type A aortic dissection: Implications for predicting dissection
- Source :
- J Thorac Cardiovasc Surg
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- OBJECTIVE: To assess ascending aortic distensibility and build geometry and distensibility-based patient-specific stress distribution maps in patients sustaining type A aortic dissection (TAAD) using pre-dissection non-invasive imaging. METHODS: Review of charts from patients undergoing surgical repair of TAAD (n=351) led to the selection of a subset population (n=7) with two or more pre-dissection CTAs and echocardiograms at least one year prior to dissection. Ascending aortic wall biomechanical properties (aortic strain, distensibility and stiffness) were compared to age and size matched non-dissected non-aneurysmal controls. Patient-specific aortic strain served as an input in aortic geometry-based simulated three-dimensional reconstructions to generate longitudinal and circumferential wall stress maps. Inspection of peri-operative dissection scans and intraoperative visual examination confirmed primary tear locations. RESULTS: Pre-dissection echocardiography revealed ascending aortas of patients sustaining TAAD to exhibit decreased aortic wall strain (14.50 ± 1.13% vs 8.49 ± 1.08%; p < 0.01), decreased distensibility (4.26 ± 0.44 vs 2.39 ± 0.33 10(−6)cm(2)dyne(−1); p < 0.01), increased stiffness (3.84 ± 0.24 vs 7.48 ± 1.05; p < 0.001), and increased longitudinal wall stress (246 ± 22 vs 172 ± 37 kPa; p < 0.01). There was no significant difference in circumferential wall stress. Pre-dissection CTA models revealed overlap between regions of increased longitudinal wall stress and primary tear sites. CONCLUSIONS: Using pre-dissection imaging, we identified increased stiffness and longitudinal wall stress in ascending aortas of dissection patients. Patient-specific imaging-derived biomechanical property maps like these may be instrumental toward designing better prediction models of aortic dissection potential.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Computed Tomography Angiography
Population
Dissection (medical)
030204 cardiovascular system & hematology
Article
03 medical and health sciences
Aortic aneurysm
Vascular Stiffness
0302 clinical medicine
Bicuspid aortic valve
Risk Factors
Stress, Physiological
Internal medicine
medicine
Humans
education
Aorta
Retrospective Studies
Computed tomography angiography
Aortic dissection
education.field_of_study
medicine.diagnostic_test
business.industry
Dissection
Perioperative
Middle Aged
medicine.disease
Aortic Aneurysm
Aortic Dissection
Blood pressure
030228 respiratory system
Echocardiography
cardiovascular system
Cardiology
Female
Surgery
Cardiology and Cardiovascular Medicine
business
Algorithms
Subjects
Details
- ISSN :
- 00225223
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- The Journal of Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....ec276f1fdd55fb145932a681ddffb555
- Full Text :
- https://doi.org/10.1016/j.jtcvs.2018.10.116