Back to Search
Start Over
Intrathecal oligoclonal bands synthesis in multiple sclerosis: is it always a prognostic factor?
- Publication Year :
- 2018
-
Abstract
- Oligoclonal IgM (OCMB) and IgG (OCGB) bands were found to be associated with poor multiple sclerosis (MS) prognosis. We aimed to evaluate the prognostic value of OCMB/OCGB in a cohort of Sardinian MS patients. We recruited patients from the University of Cagliari. They underwent lumbar puncture for diagnostic purposes. Demographic and the following clinical data were recorded: clinical course; time to reach EDSS 3 and 6; EDSS at last follow-up; and MS treatments. The influence of gender, clinical course, age at onset, treatments, and OCGB/OCMB on reaching EDSS 3 was analysed using Cox regression. Kaplan–Meier curves were used to study the time to reach EDSS 3 considering OCMB/OCGB and therapies. The enrolled number of subjects was 503. The variables influencing the achievement of EDSS 3.0 were: male gender (p = 0.005); progressive course (p = 0.001); age at onset (p
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Prognostic factor
Neurology
Multiple Sclerosis
Adolescent
Kaplan-Meier Estimate
Intrathecal
Cohort Studies
03 medical and health sciences
Disability Evaluation
Young Adult
0302 clinical medicine
Internal medicine
medicine
Humans
Intrathecal oligoclonal bands
MS disability
Multiple sclerosis
Prognostic factors
Sardinia
Child
Neuroradiology
Aged
medicine.diagnostic_test
Lumbar puncture
Proportional hazards model
business.industry
Oligoclonal Bands
Middle Aged
medicine.disease
030104 developmental biology
Immunoglobulin M
Italy
Spinal Cord
Immunoglobulin G
Cohort
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ec122385b053b19d43c18c0d5d8c5118