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Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report
- Source :
- American Journal of Psychiatry. 160:1519-1522
- Publication Year :
- 2003
- Publisher :
- American Psychiatric Association Publishing, 2003.
-
Abstract
- The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women.Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17beta-estradiol (100 micro g/day) for 4 weeks. The Montgomery-Asberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression (CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score10 on the Montgomery-Asberg Depression Rating Scale and a score/=2 on the CGI at week 4.Remission of depression was noted in eight of the 20 women who completed the study; two of these women were postmenopausal, and six were perimenopausal. Antidepressant response was not associated with severity or subtypes of depression at study entry or with concomitant improvement in menopause-related symptoms.Some perimenopausal women with depression may benefit from short-term use of estrogen therapy, and its role for postmenopausal depressed women warrants further investigation. Antidepressant benefit associated with estrogen therapy may be independent of improvement in physical symptoms.
- Subjects :
- Adult
medicine.medical_specialty
Personality Inventory
medicine.drug_class
Osteoporosis
Administration, Cutaneous
Internal medicine
medicine
Humans
Depression (differential diagnoses)
Climacteric
Psychiatric Status Rating Scales
Gynecology
Depressive Disorder
Estradiol
Vasomotor
business.industry
Estrogen Replacement Therapy
Middle Aged
medicine.disease
Postmenopause
Menopause
Psychiatry and Mental health
Treatment Outcome
Sexual dysfunction
Estrogen
Antidepressant
Female
medicine.symptom
business
Psychosocial
Subjects
Details
- ISSN :
- 15357228 and 0002953X
- Volume :
- 160
- Database :
- OpenAIRE
- Journal :
- American Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....ec1078627403de4c7caa9bc9c61929af