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Unscreened older men diagnosed with prostate cancer are at increased risk of aggressive disease
- Source :
- Prostate cancer and prostatic diseases. 20(2)
- Publication Year :
- 2016
-
Abstract
- To evaluate the relationship between PSA testing history and high-risk disease among older men diagnosed with prostate cancer. Records from 1993 to 2014 were reviewed for men who underwent radiotherapy for prostate cancer at age 75 years or older. Patients were classified into one of four groups based on PSA-testing history: (1) no PSA testing; (2) incomplete/ineffective PSA testing; (3) PSA testing; or (4) cannot be determined. Outcomes of interest were National Comprehensive Cancer Network (NCCN) risk group (that is, low, intermediate or high risk) and biopsy grade at diagnosis. Multivariable logistic regression was used to determine the association between PSA testing history and high-risk cancer. PSA-testing history was available in 274 (94.5%) of 290 subjects meeting study criteria. In total, 148 men (54.0%) underwent PSA testing with follow-up biopsy, 72 (26.3%) underwent PSA testing without appropriate follow-up, and 54 men (19.7%) did not undergo PSA testing. Patients who underwent PSA testing were significantly less likely to be diagnosed with NCCN high-risk cancer (23.0% vs 51.6%, P
- Subjects :
- PCA3
Oncology
Male
Cancer Research
medicine.medical_specialty
Urology
medicine.medical_treatment
Biopsy
Population
030232 urology & nephrology
Prostatitis
urologic and male genital diseases
Risk Assessment
Article
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
education
Early Detection of Cancer
Aged
Aged, 80 and over
education.field_of_study
Prostatectomy
business.industry
Age Factors
Prostate
Cancer
Prostatic Neoplasms
Odds ratio
Prostate-Specific Antigen
medicine.disease
Prostate-specific antigen
Logistic Models
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 14765608
- Volume :
- 20
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Prostate cancer and prostatic diseases
- Accession number :
- edsair.doi.dedup.....ec100f46026666256d0a3253ce90f9d9