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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy
- Source :
- Nature nanotechnology
- Publication Year :
- 2017
-
Abstract
- Immunotherapy holds tremendous promise for improving cancer treatment. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the 'abscopal effect'. Unfortunately, response rates for this strategy remain low. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties. We showed that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of αPD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs. Mechanistic studies revealed that AC-NPs induced an expansion of CD8+ cytotoxic T cells and increased both CD4+T/Treg and CD8+T/Treg ratios (Treg, regulatory T cells). Our work presents a novel strategy to improve cancer immunotherapy with nanotechnology.
- Subjects :
- medicine.medical_treatment
Biomedical Engineering
Bioengineering
Nanotechnology
02 engineering and technology
010402 general chemistry
01 natural sciences
Article
Immune system
Cancer immunotherapy
Antigen
medicine
Cytotoxic T cell
General Materials Science
Electrical and Electronic Engineering
business.industry
Melanoma
Abscopal effect
Immunotherapy
021001 nanoscience & nanotechnology
Condensed Matter Physics
medicine.disease
Atomic and Molecular Physics, and Optics
3. Good health
0104 chemical sciences
Cancer research
0210 nano-technology
business
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 17483395 and 17483387
- Volume :
- 12
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Nature nanotechnology
- Accession number :
- edsair.doi.dedup.....ec0a40446a012c0ff2f10c69a7881880