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Efficacy of an experimental azithromycin cream for prophylaxis of tick-transmitted lyme disease spirochete infection in a murine model
- Source :
- Antimicrobial agents and chemotherapy. 58(1)
- Publication Year :
- 2013
-
Abstract
- As an alternative to oral prophylaxis for the prevention of tick transmission of Borrelia burgdorferi , we tested antibiotic cream prophylactic formulations in a murine model of spirochete infection. A 4% preparation of doxycycline cream afforded no protection, but a single application of 4% azithromycin cream was 100% protective when applied directly to the tick bite site at the time of tick removal. Indeed, the azithromycin cream was 100% effective when applied at up to 3 days after tick removal and protected 74% of mice exposed to tick bite when applied at up to 2 weeks after tick removal. Azithromycin cream was also protective when applied at a site distal to the tick bite site, suggesting that it was having a systemic effect in addition to a local transdermal effect. Mice that were protected from tick-transmitted infection did not seroconvert and did not infect larval ticks on xenodiagnosis. Azithromycin cream formulations appear to hold promise for Lyme disease prophylaxis.
- Subjects :
- medicine.drug_class
Antibiotics
Tick
Azithromycin
Microbiology
Mice
Lyme disease
Ticks
parasitic diseases
medicine
Animals
Pharmacology (medical)
Experimental Therapeutics
Borrelia burgdorferi
Pharmacology
Doxycycline
Lyme Disease
biology
digestive, oral, and skin physiology
food and beverages
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Virology
Anti-Bacterial Agents
Infectious Diseases
Lyme disease microbiology
Female
Xenodiagnosis
medicine.drug
Subjects
Details
- ISSN :
- 10986596
- Volume :
- 58
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....ec08fe243ce6f3e1c658131b803c4620