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Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
- Source :
- Nature Medicine. 23:1146-1149
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
- Subjects :
- 0301 basic medicine
medicine.drug_class
viruses
Enzyme-Linked Immunosorbent Assay
Cross Reactions
Biology
Antibodies, Viral
Monoclonal antibody
medicine.disease_cause
Article
General Biochemistry, Genetics and Molecular Biology
West africa
Random Allocation
03 medical and health sciences
Lassa Fever
0302 clinical medicine
medicine
Animals
Humans
030212 general & internal medicine
Lassa virus
Lassa fever
Monoclonal antibody therapy
Immune Evasion
Advanced stage
Antibodies, Monoclonal
virus diseases
General Medicine
Viral Load
medicine.disease
Antibodies, Neutralizing
Immunohistochemistry
Virology
Survival Rate
Macaca fascicularis
030104 developmental biology
Immunology
biology.protein
RNA, Viral
Antibody
Viral load
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi.dedup.....ec0800cb82ffc34ddc20c317171c9aa3