Back to Search
Start Over
Hyperthermic intraperitoneal chemoperfusion (HIPEC) decrease wound strength of colonic anastomosis in a rat model
- Source :
- International Journal of Colorectal Disease. 22:941-947
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- There is controversy about the effect of the influence of hyperthermia and chemotherapeutic agents on the healing of intestinal anastomosis. The effects of hyperthermic intraperitoneal chemoperfusion (HIPEC) of wound healing after colonic anastomosis were investigated in a rat model.Thirty-six Wag/Rija rats were randomized into three groups of 12 animals each: group I: control (only colonic anastomosis was performed) (n = 12); group II: HIPEC (mitomycin C in a concentration of 20 mg/m(2) (n = 12) colonic anastomosis was performed before HIPEC; group III: HIPEC (mitomycin C in a concentration of 20 mg/m(2) (n = 12) colonic anastomosis was performed after HIPEC. Bursting pressure and bursting sites were recorded 4 and 10 days after intervention. Collagen deposits, inflammation and foreign body reactions were evaluated.Lower bursting pressure and lost of collagen were found in both HIPEC groups and compared with the control group. There was almost no difference between both HIPEC groups. They were noted overwhelmingly at the anastomosis in the HIPEC group. The degree of collagen accumulation was well-correlated with bursting pressure.These results have shown that hyperthermic intraperitoneal chemoperfusion (HIPEC) impairs wound healing in colonic anastomosis in rats.
- Subjects :
- Male
Hyperthermia
medicine.medical_specialty
Time Factors
Colon
Mitomycin
medicine.medical_treatment
Down-Regulation
Anastomosis
Surgical anastomosis
Hypothermia, Induced
Colon surgery
Tensile Strength
Pressure
medicine
Animals
Digestive System Surgical Procedures
Inflammation
Wound Healing
Chemotherapy
Antibiotics, Antineoplastic
business.industry
Foreign-Body Reaction
Anastomosis, Surgical
Mitomycin C
Gastroenterology
Rats, Inbred Strains
Hypothermia
medicine.disease
Rats
Surgery
Chemotherapy, Cancer, Regional Perfusion
Anesthesia
Models, Animal
Collagen
medicine.symptom
Wound healing
business
Subjects
Details
- ISSN :
- 14321262 and 01791958
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Colorectal Disease
- Accession number :
- edsair.doi.dedup.....ebfed1f82ab9e4a0d4a99e6fd8ed4903