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Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients
- Source :
- BMC Cancer, Vol 18, Iss 1, Pp 1-8 (2018), BMC Cancer
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients’ overall metabolic tumour burden (MTB). Methods Thirty-two treatment naïve metastatic melanoma patients were included in the study. MTB and metabolic tumour volume (MTV) was measured by 18F-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT). Plasma ctDNA was quantified using droplet digital PCR (ddPCR). Results CtDNA was detected in 23 of 32 patients. Overall, a significant correlation was observed between ctDNA levels and MTB (p
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
lcsh:RC254-282
Circulating Tumor DNA
Correlation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Surgical oncology
Positron Emission Tomography Computed Tomography
Internal medicine
Genetics
medicine
Humans
Digital polymerase chain reaction
Melanoma
Aged
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
medicine.diagnostic_test
Proportional hazards model
business.industry
Metabolic tumour burden
Cancer
ctDNA
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Tumor Burden
030104 developmental biology
chemistry
Tumour lesion glycolysis
Droplet digital PCR
Positron emission tomography
030220 oncology & carcinogenesis
Female
business
Circulating tumour DNA
DNA
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....ebf3583706e0f81266dddc277880768e