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Control of Invasion by Epithelial-to-Mesenchymal Transition Programs during Metastasis
- Source :
- Journal of Clinical Medicine, Vol 8, Iss 5, p 646 (2019), Journal of Clinical Medicine
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Epithelial-to-mesenchymal transition (EMT) programs contribute to the acquisition of invasive properties that are essential for metastasis. It is well established that EMT programs alter cell state and promote invasive behavior. This review discusses how rather than following one specific program, EMT states are diverse in their regulation and invasive properties. Analysis across a spectrum of models using a combination of approaches has revealed how unique features of distinct EMT programs dictate whether tumor cells invade as single cells or collectively as cohesive groups of cells. It has also been shown that the mode of collective invasion is determined by the nature of the EMT, with cells in a trailblazer-type EMT state being capable of initiating collective invasion, whereas cells that have undergone an opportunist-type EMT are dependent on extrinsic factors to invade. In addition to altering cell intrinsic properties, EMT programs can influence invasion through non-cell autonomous mechanisms. Analysis of tumor subpopulations has demonstrated how EMT-induced cells can drive the invasion of sibling epithelial populations through paracrine signaling and remodeling of the microenvironment. Importantly, the variation in invasive properties controlled by EMT programs influences the kinetics and location of metastasis.
- Subjects :
- Cell
lcsh:Medicine
Cell state
Tumor cells
Review
Metastasis
03 medical and health sciences
Paracrine signalling
0302 clinical medicine
medicine
metastasis
Epithelial–mesenchymal transition
030304 developmental biology
0303 health sciences
collective invasion
hybrid
business.industry
lcsh:R
General Medicine
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
embryonic structures
Cancer research
epithelial-to-mesenchymal transition
heterogeneity
business
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....ebe6b788f02d451573de47803c340cbb