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An ultrasensitive photoelectrochemical biosensor for glucose based on bio-derived nitrogen-doped carbon sheets wrapped titanium dioxide nanoparticles
- Source :
- Biosensorsbioelectronics. 126
- Publication Year :
- 2018
-
Abstract
- In this work, an ultra-sensing photoelectrochemical (PEC) glucose biosensor has been constructed from the bio-derived nitrogen-doped carbon sheets (NDC) wrapped titanium dioxide nanoparticles (NDC-TiO2 NPs) followed by the covalent immobilization of glucose oxidase (GODx) on them (designated as a GODx/NDC-TiO2NPs/ITO biosensor). Initially, the TiO2 NPs was synthesized by sol-gel method and then NDC-TiO2 NPs was synthesized utilizing a green source of Prunus persica (peach fruit) through a simple hydrothermal process. The synthesized NDC-TiO2 NPs composite was characterized by FESEM, HRTEM, Raman spectroscopy, XRD, ATR-FTIR spectroscopy and XPS to determine composition and phase purity. These fabricated GODx/NDC-TiO2NPs/ITO biosensor exhibited a good charge separation, highly enhanced and stable photocurrent responses with switching PEC behavior under the light (λ > 400 nm). As a result, GODx/NDC-TiO2NPs/ITO PEC glucose sensor exhibits a good photocurrent response to detection of glucose concentrations (0.05–10 μM) with an ultra-low detection limit of 13 nM under optimized PEC experimental conditions. Also, the PEC glucose sensor revealed a high selectivity, good stability, long time durability, and capability to analyze the glucose levels in real human serum. Also, the further development of this work may provide new insights into preparing other bio-derived carbon nanostructure-based photocatalysts for PEC applications.
- Subjects :
- Blood Glucose
Materials science
Nitrogen
Photoelectrochemistry
Biomedical Engineering
Biophysics
chemistry.chemical_element
02 engineering and technology
Biosensing Techniques
01 natural sciences
chemistry.chemical_compound
X-ray photoelectron spectroscopy
Electrochemistry
Humans
Glucose oxidase
High-resolution transmission electron microscopy
Photocurrent
Titanium
biology
010401 analytical chemistry
General Medicine
Electrochemical Techniques
021001 nanoscience & nanotechnology
Carbon
0104 chemical sciences
Glucose
chemistry
Chemical engineering
Titanium dioxide
biology.protein
Nanoparticles
0210 nano-technology
Biosensor
Biotechnology
Subjects
Details
- ISSN :
- 18734235
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Biosensorsbioelectronics
- Accession number :
- edsair.doi.dedup.....ebdee8996234f8467ce42ae734eccb13