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'Small' talk: Opa proteins as mediators of Neisseria–host-cell communication
- Source :
- Current Opinion in Microbiology. 6:43-49
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells. They have emerged as a paradigm of a bacterial toolbox allowing recognition of different host receptors and orchestrating the cell type tropism displayed by pathogenic Neisseriae. Recent work has highlighted the molecular basis of Opa-protein-host-receptor interaction and has shed new light on the functional consequences of this interaction with regard to bacterial attachment, invasion, and responses elicited in particular host cells.
- Subjects :
- Microbiology (medical)
Cell type
Neisseriaceae Infections
Meningitis, Meningococcal
Neisseria meningitidis
medicine.disease_cause
Models, Biological
Microbiology
Gonorrhea
Antigen
ddc:570
medicine
Humans
Receptor
Tropism
Antigens, Bacterial
biology
Epithelial Cells
biology.organism_classification
Neisseria gonorrhoeae
Infectious Diseases
Neisseria
Bacterial outer membrane
Bacterial Outer Membrane Proteins
Subjects
Details
- ISSN :
- 13695274
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Microbiology
- Accession number :
- edsair.doi.dedup.....ebc85c12cac6b64bb63398cba81e5eeb