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Gut microbiome in type 1 diabetes: A comprehensive review
- Source :
- Diabetes/Metabolism Research and Reviews
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Summary Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome‐wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D has been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D‐triggering factors, especially environmental factors. In this review, we summarize the current aetiological and mechanism studies of gut microbiome in T1D. A better understanding of the role of gut microbiome in T1D may provide us with powerful prognostic and therapeutic tools in the near future.
- Subjects :
- 0301 basic medicine
endocrine system
endocrine system diseases
type 1 diabetes
Endocrinology, Diabetes and Metabolism
gut microbiome
Review Article
03 medical and health sciences
Disease susceptibility
Endocrinology
environmental factors
Internal Medicine
medicine
Genetic predisposition
Animals
Humans
genetics
Review Articles
Genetic association
Genetics
Type 1 diabetes
Mechanism (biology)
business.industry
Gastrointestinal Microbiome
nutritional and metabolic diseases
medicine.disease
Gut microbiome
immune system
Diabetes Mellitus, Type 1
030104 developmental biology
Disease Susceptibility
business
Subjects
Details
- ISSN :
- 15207552
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Diabetes/Metabolism Research and Reviews
- Accession number :
- edsair.doi.dedup.....ebb2e78857eb62b2da2536467a2be037