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Sex differences in the risk of vascular disease associated with diabetes
- Source :
- Biology of Sex Differences, Biology of Sex Differences, Vol 11, Iss 1, Pp 1-11 (2020), Biology of Sex Differences, 11(1). BMC
- Publication Year :
- 2020
-
Abstract
- Diabetes is a strong risk factor for vascular disease. There is compelling evidence that the relative risk of vascular disease associated with diabetes is substantially higher in women than men. The mechanisms that explain the sex difference have not been identified. However, this excess risk could be due to certain underlying biological differences between women and men. In addition to other cardiometabolic pathways, sex differences in body anthropometry and patterns of storage of adipose tissue may be of particular importance in explaining the sex differences in the relative risk of diabetes-associated vascular diseases. Besides biological factors, differences in the uptake and provision of health care could also play a role in women’s greater excess risk of diabetic vascular complications. In this review, we will discuss the current knowledge regarding sex differences in both biological factors, with a specific focus on sex differences adipose tissue, and in health care provided for the prevention, management, and treatment of diabetes and its vascular complications. While progress has been made towards understanding the underlying mechanisms of women’s higher relative risk of diabetic vascular complications, many uncertainties remain. Future research to understanding these mechanisms could contribute to more awareness of the sex-specific risk factors and could eventually lead to more personalized diabetes care. This will ensure that women are not affected by diabetes to a greater extent and will help to diminish the burden in both women and men.
- Subjects :
- Male
medicine.medical_specialty
BODY-COMPOSITION
STATIN THERAPY
Adipose tissue
lcsh:Medicine
030209 endocrinology & metabolism
Review
030204 cardiovascular system & hematology
lcsh:Physiology
Gender Studies
Diabetes Complications
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
MEDICATION NONADHERENCE
64 COHORTS
Risk Factors
Diabetes mellitus
medicine
Humans
CORONARY-HEART-DISEASE
Vascular Diseases
Risk factor
Healthcare Disparities
Intensive care medicine
Adiposity
GENDER-DIFFERENCES
INSULIN-RESISTANCE
Sex Characteristics
lcsh:QP1-981
Vascular disease
business.industry
lcsh:R
Absolute risk reduction
medicine.disease
RACIAL DISPARITIES
3. Good health
CARDIOVASCULAR-DISEASE
Relative risk
Female
QUALITY-OF-CARE
business
Sex characteristics
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biology of Sex Differences, Biology of Sex Differences, Vol 11, Iss 1, Pp 1-11 (2020), Biology of Sex Differences, 11(1). BMC
- Accession number :
- edsair.doi.dedup.....eba5da3b0cd8f9fc520fa5f6b6ae25f3