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Feijoa sellowiana Berg Fruit Juice: Anti-Inflammatory Effect and Activity on Superoxide Anion Generation
- Source :
- Journal of Medicinal Food. 17:455-461
- Publication Year :
- 2014
- Publisher :
- Mary Ann Liebert Inc, 2014.
-
Abstract
- Feijoa sellowiana Berg var. coolidge fruit juice was studied in vivo for the anti-inflammatory activity by carrageenin-induced paw edema test and in vitro for the effects on superoxide anion release from neutrophils in human whole blood. The fruit juice was analyzed by the high-performance liquid chromatography method, and quercetin, ellagic acid, catechin, rutin, eriodictyol, gallic acid, pyrocatechol, syringic acid, and eriocitrin were identified. The results showed a significant anti-inflammatory activity of F. sellowiana fruit juice, sustained also by an effective antioxidant activity observed in preliminary studies on 1,1-diphenyl-2-picrylhydrazyl (DPPH) test. In particular, the anti-inflammatory activity edema inhibition is significant since the first hour (44.11%) and persists until the fifth hour (44.12%) of the treatment. The effect on superoxide anion release was studied in human whole blood, in the presence of activators affecting neutrophils by different mechanisms. The juice showed an inhibiting response on neutrophils basal activity in all experimental conditions. In stimulated neutrophils, the higher inhibition of superoxide anion generation was observed at concentration of 10(-4) and 10(-2) mg/mL in whole blood stimulate with phorbol-myristate-13-acetate (PMA; 20% and 40%) and with N-formyl-methionyl-leucyl-phenylalanine (FMLP; 15% and 48%). The significant reduction of edema and the inhibition of O2(-) production, occurring mainly through interaction with protein-kinase C pathway, confirm the anti-inflammatory effect of F. sellowiana fruit juice.
- Subjects :
- Anions
Male
Neutrophils
Anti-Inflammatory Agents
Medicine (miscellaneous)
Antioxidants
Beverages
Feijoa
chemistry.chemical_compound
Superoxides
Animals
Edema
Humans
Gallic acid
Food science
Rats, Wistar
Antiinflammatory activity
Feijoa sellowiana Berg
HPLC
Polyphenols
Superoxide anion
Nutrition and Dietetics
Plant Extracts
Superoxide
Catechin
Eriodictyol
Syringic acid
Rats
chemistry
Biochemistry
Fruit
Quercetin
Eriocitrin
Ellagic acid
Subjects
Details
- ISSN :
- 15577600 and 1096620X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Food
- Accession number :
- edsair.doi.dedup.....eb99a86e1a21c79144e13fa125e0c525