Back to Search
Start Over
Human epidermal stem cell function is regulated by circadian oscillations
- Source :
- Cell Stem Cell; Vol 13, Recercat. Dipósit de la Recerca de Catalunya, instname, Cell Stem Cell
- Publication Year :
- 2013
- Publisher :
- Elsevier, 2013.
-
Abstract
- Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and phased manner, establishing distinct temporal intervals during the 24 hr day period. Each of these successive clock waves is associated with a peak in the expression of subsets of transcripts that temporally segregate the predisposition of epidermal stem cells to respond to cues that regulate their proliferation or differentiation, such as TGFβ and calcium. Accordingly, circadian arrhythmia profoundly affects stem cell function in culture and in vivo. We hypothesize that this intricate mechanism ensures homeostasis by providing epidermal stem cells with environmentally relevant temporal functional cues during the course of the day and that its perturbation may contribute to aging and carcinogenesis. This work has been funded by an ERC Consolidator Grant (STEMCLOCK) to S.A.B. and by the PROSPECTS, grant agreement number HEALTH-F4-2008-201648, to L.S. from the European Union. G.S. is funded by an AXA Fund fellowship. K.T. is funded by a La Caixa Ph.D. fellowship./nResearch in the lab of B.L. is funded by the European Research Council (ERC), MINECO Plan Nacional grant BFU2011-26206, ERASysBio+ ERANET project EUI2009-04059 GRAPPLE, the EMBO Young Investigator Program, EU Framework 7 project 277899 4DCellFate, and the EMBL/CRG Systems Biology Program
- Subjects :
- Keratinocytes
Male
medicine.medical_specialty
Time Factors
CLOCK Proteins
Human skin
Biology
medicine.disease_cause
Epidermis -- Citologia
03 medical and health sciences
Mice
0302 clinical medicine
In vivo
Transforming Growth Factor beta
Internal medicine
Genetics
medicine
Animals
Humans
Circadian rhythm
Ritmes circadiaris -- Efectes fisiològics
Cells, Cultured
health care economics and organizations
030304 developmental biology
Cell Proliferation
0303 health sciences
Cèl·lules mare -- Citologia
integumentary system
Stem Cells
Infant, Newborn
Cell Differentiation
Cell Biology
3. Good health
Cell biology
Circadian Rhythm
CLOCK
Mice, Inbred C57BL
Endocrinology
Epidermal Cells
Epidermal stem cell
Molecular Medicine
Calcium
Stem cell
Carcinogenesis
030217 neurology & neurosurgery
Homeostasis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cell Stem Cell; Vol 13, Recercat. Dipósit de la Recerca de Catalunya, instname, Cell Stem Cell
- Accession number :
- edsair.doi.dedup.....eb9351947594bccea4ce93c2614226f9