The Underestimated Burden of Monogenic Diseases in Adult-Onset ESRD

The primary cause of ESRD remains unresolved in 15%–20% of adult patients, a percentage probably underestimated considering that the nonspecific diagnoses of hypertension- and renal vascular–related CKD represent 20%–25% of patients with ESRD.[1][1],[2][2] As genomic testing is more commonly