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Torg-Winchester syndrome: lack of efficacy of pamidronate therapy
- Source :
- Clinical dysmorphology. 16(2)
- Publication Year :
- 2007
-
Abstract
- Torg-Winchester syndrome, which includes nodular arthropathy with osteolysis (OMIM 605156), is a condition associated with generalized osteoporosis. On the basis of usefulness of pamidronate in conditions with osteoporosis, we hypothesized that the drug will improve osteolysis and/or osteoporosis in this condition. After obtaining informed consent from the parents, two siblings affected with Torg-Winchester syndrome were administered intravenous pamidronate over a period of 3 years. The clinical status was monitored along with the bone mineral density (using radiographs and X-ray densitometry) to assess the effect of the drug. Clinically there was no improvement. Although the bone mineral density improved in axial skeleton, osteoporosis and osteolysis continued to worsen in the appendicular skeleton. We conclude that pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by mutation in matrix metalloproteinase 2 gene.
- Subjects :
- Male
medicine.medical_specialty
Osteolysis
Axial skeleton
Bone density
Appendicular skeleton
Osteoporosis
Pamidronate
Pathology and Forensic Medicine
Bone Density
Internal medicine
Arthropathy
medicine
Humans
Abnormalities, Multiple
Child
Genetics (clinical)
Bone mineral
Bone Diseases, Developmental
Bone Density Conservation Agents
Diphosphonates
business.industry
General Medicine
Syndrome
Hand Deformities
medicine.disease
Radiography
medicine.anatomical_structure
Treatment Outcome
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
Anatomy
business
Subjects
Details
- ISSN :
- 09628827
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical dysmorphology
- Accession number :
- edsair.doi.dedup.....eb86d9adeeae711c5f376011117e49b2