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Hare TRIM5α Restricts Divergent Retroviruses and Exhibits Significant Sequence Variation from Closely Related Lagomorpha TRIM5 Genes
- Source :
- Journal of Virology. 84:12463-12468
- Publication Year :
- 2010
- Publisher :
- American Society for Microbiology, 2010.
-
Abstract
- TRIM5α proteins recruit and restrict incoming cytoplasmic retroviruses. Primate TRIM5α sequence diversity underlies species-specific restriction and is likely caused by selective pressure from ancient pathogenic infections. Here we show that TRIM5α from the European brown hare restricts diverse retroviruses. Furthermore, it differs significantly in sequence from TRIM5α from the closely related rabbit, suggesting evolutionary changes in the last 12 million years since these species diverged. We propose that, like primates, lagomorphs have been subject to selective pressure from TRIM5-sensitive viruses, possibly related to the endogenous lentivirus RELIK found in both rabbits and hares.
- Subjects :
- Brown hare
Genetic Vectors
Green Fluorescent Proteins
Molecular Sequence Data
Immunology
Microbiology
Evolution, Molecular
Species Specificity
Virology
biology.animal
Animals
Primate
Amino Acid Sequence
Cloning, Molecular
Sequence variation
Gene
DNA Primers
Sequence (medicine)
Genetics
Likelihood Functions
Lagomorpha
Base Sequence
Models, Genetic
biology
Genetic Variation
Sequence Analysis, DNA
Hares
biology.organism_classification
Retroviridae
Genetic Diversity and Evolution
Insect Science
Lentivirus
Capsid Proteins
Carrier Proteins
Sequence Alignment
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....eb7c5ee94e92c74290c2ba51eb4b7e84