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Effectiveness of electroconvulsive therapy in patients with 'less treatment‐resistant' depression by the Maudsley Staging Model
- Source :
- Brain and Behavior, Vol 10, Iss 7, Pp n/a-n/a (2020), Brain and Behavior
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Introduction Electroconvulsive therapy (ECT) is an effective treatment for patients with mood disorders and is most often used for treatment‐resistant cases. This study aimed to examine the effectiveness of ECT in a real‐world treatment sample in a Chinese psychiatric hospital which included both treatment‐resistant and nontreatment‐resistant patients. Methods An observational study of symptom outcomes from admission to the time of discharge was conducted with 37 inpatients diagnosed with unipolar or bipolar depression treated with ECT. Symptom severity was assessed with the 17‐item Hamilton Rating Scales for Depression (HRSD‐17) and treatment‐resistance with the Maudsley Staging Model (MSM). Stratifying at the MSM median admission characteristics and symptom change was compared between patients who were treatment‐resistant (n = 18) and who were not (n = 19). The outcome difference between groups was compared using analyses of covariance adjusted for baseline characteristics including symptom severity, followed by linear regression to identify factors associated symptom improvement in the entire sample. Results The sample (n = 37) showed moderate treatment‐resistance (MSM = 7.30 ± 1.13) at admission and both groups received 8.3 ± 2 ECT sessions. The treatment‐resistant group had a smaller proportion of bipolar patients and more severe symptoms, but showed no significant difference from the nontreatment‐resistant group in HDRS‐17 scores at the time of discharge (adjusted means = 6.23 ± 1.00 vs. 5.94 ± 0.97, Partial η 2 = 0.001, p = .845). Baseline symptom severity was the strongest correlate of reduction in HDRS‐17 scores (β = 0.891, p<br />The reduction of depressive symptoms with ECT does not appear to be affected by overall “treatment‐resistance” but is greatest for those with the most severe symptoms at baseline.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
effectiveness
behavioral disciplines and activities
050105 experimental psychology
electroconvulsive therapy
law.invention
lcsh:RC321-571
03 medical and health sciences
Behavioral Neuroscience
Depressive Disorder, Treatment-Resistant
0302 clinical medicine
Electroconvulsive therapy
Randomized controlled trial
law
Internal medicine
mental disorders
Medicine
Psychiatric hospital
Humans
0501 psychology and cognitive sciences
depression symptoms severity
treatment‐resistance
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Depression (differential diagnoses)
Original Research
Psychiatric Status Rating Scales
business.industry
Depression
05 social sciences
Rating scales for depression
medicine.disease
Treatment Outcome
Mood disorders
Observational study
Female
business
Treatment-resistant depression
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 21623279
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Brain and Behavior
- Accession number :
- edsair.doi.dedup.....eb784df317585e60ef9cddaf0a96a290