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Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity
- Source :
- Molecules and Cells
- Publication Year :
- 2014
- Publisher :
- Korean Society for Molecular and Cellular Biology, 2014.
-
Abstract
- Recent findings, notably on adipokines and adipose tissue inflammation, have revised the concept of adipose tissues being a mere storage depot for body energy. Instead, adipose tissues are emerging as endocrine and immunologically active organs with multiple effects on the regulation of systemic energy homeostasis. Notably, compared with other metabolic organs such as liver and muscle, various inflammatory responses are dynamically regulated in adipose tissues and most of the immune cells in adipose tissues are involved in obesity-mediated metabolic complications, including insulin resistance. Here, we summarize recent findings on the key roles of innate (neutrophils, macrophages, mast cells, eosinophils) and adaptive (regulatory T cells, type 1 helper T cells, CD8 T cells, B cells) immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. In particular, the roles of natural killer T cells, one type of innate lymphocyte, in adipose tissue inflammation will be discussed. Finally, a new role of adipocytes as antigen presenting cells to modulate T cell activity and subsequent adipose tissue inflammation will be proposed.
- Subjects :
- obesity
Neutrophils
Adipose Tissue, White
Adipose tissue macrophages
T cell
Adipose tissue
Inflammation
macrophage
Biology
adipocyte
CD1d
chemistry.chemical_compound
Immune system
Adipocyte
Adipocytes
medicine
Animals
Humans
Lymphocytes
Mast Cells
adipose tissue inflammation
Molecular Biology
Macrophages
Innate lymphoid cell
CD4 T cell
Cell Biology
General Medicine
Natural killer T cell
Eosinophils
antigen presentation
medicine.anatomical_structure
CD8 T cell
chemistry
Immunology
Minireview
invariant natural killer T cell
Insulin Resistance
medicine.symptom
Subjects
Details
- ISSN :
- 02191032 and 10168478
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Molecules and Cells
- Accession number :
- edsair.doi.dedup.....eb70769d31000bd3a262b89ec7c57d38