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Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project
- Source :
- Journal of Nephrology
- Publication Year :
- 2022
- Publisher :
- Springer, 2022.
-
Abstract
- Background Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on the mechanisms underlying the excess of cardiovascular mortality associated with both chronic kidney disease and hyperuricemia and lead to better risk stratification. Our main goal was to study the relationships between serum uric acid and kidney disease measures (namely estimated GFR [eGFR] and albuminuria) in a large cohort of individuals at cardiovascular risk from the URic acid Right for heArt Health (URRAH) Project database. Methods Clinical data of 26,971 individuals were analyzed. Factors associated with the presence of hyperuricemia defined on the basis of previously determined URRAH cutoffs for cardiovascular and all-cause mortality were evaluated through multivariate analysis. Chronic kidney disease was defined as eGFR 2 and/or abnormal urinary albumin excretion diagnosed as: (i) microalbuminuria if urinary albumin concentration was > 30 and ≤ 300 mg/L, or if urinary albumin-to-creatinine ratio (ACR) was > 3.4 mg/mmol and ≤ 34 mg/mmol; (ii) macroalbuminuria if urinary albumin concentration was > 300 mg/L, or if ACR was > 34 mg/mmol. Results Mean age was 58 ± 15 years (51% males, 62% with hypertension and 12% with diabetes), mean eGFR was 81 ml/min per 1.73m22with a prevalence of eGFR Conclusions The lower the eGFR the higher the prevalence of hyperuricemia and gout. In subjects with eGFR 90 ml/min. The percentage of individuals treated with allopurinol was below 2% when GFR was above 60 ml/min, it increased to 20% in the presence of CKD 3b and rose further to 35% in individuals with macroalbuminuria. Graphic abstract
- Subjects :
- Nephrology
Adult
Male
medicine.medical_specialty
Settore MED/09 - Medicina Interna
030232 urology & nephrology
Allopurinol
Renal function
Hyperuricemia
030204 cardiovascular system & hematology
Kidney
urologic and male genital diseases
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Serum uric acid
Risk Factors
Internal medicine
Diabetes mellitus
medicine
eGFR
Humans
Albuminuria
Renal Insufficiency, Chronic
Aged
business.industry
Cardiovascular risk
nutritional and metabolic diseases
Middle Aged
medicine.disease
Uric Acid
chemistry
Uric acid
Original Article
Female
medicine.symptom
business
medicine.drug
Kidney disease
Glomerular Filtration Rate
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....eb59551ba09083f4a15bde8143bd9130