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Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, maternal and cord serum of French women and their newborns
- Source :
- Environment International, Vol 84, Iss, Pp 71-81 (2015), Environment International, Environment International, Elsevier, 2015, 84, pp.71-81. ⟨10.1016/j.envint.2015.07.014⟩
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- One major concern regarding perfluoroalkyl acids (PFAAs) is their potential role in onset of health troubles consecutive to early exposure during the perinatal period. In the present work, the internal exposure levels of 18 targeted PFAAs were determined in ca. 100 mother–newborn pairs recruited in France between 2010 and 2013. In serum, the cumulated concentrations of the 7 most frequently detected compounds were 5.70 ng/mL and 2.83 ng/mL (median values) in maternal and cord serum, respectively. Perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexylesulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) contributed to around 90% of the total PFAAs contamination, with concentration levels and contamination profiles in accordance with other published work in Europe. Levels measured in breast milk were far lower (20 to 150 fold) than those determined in serum. Associations between the different monitored substances as well as between levels determined in the different investigated biological matrices mostly do not appear statistically significant. The estimated materno-foetal transfer would be thus substance-dependant, mainly driven by the physico-chemical properties of the different PFAAs (nature of polar group and length of alkylated side chain). We conclude that trans-placental passage and breastfeeding are both significant routes of human exposure to PFAAs. Keywords: Perfluoroalkyl substances, Endocrine disruptors, Perinatal exposure, Biomonitoring, Profiling
- Subjects :
- Perfluorooctanesulfonic acid
Physiology
Breast milk
Perfluorononanoic acid
Toxicology
chemistry.chemical_compound
Pregnancy
CORD SERUM
Biomonitoring
Animals
Humans
Endocrine disruptors
lcsh:Environmental sciences
General Environmental Science
lcsh:GE1-350
Fluorocarbons
Milk, Human
Perinatal Exposure
Chemistry
Profiling
Infant, Newborn
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Fetal Blood
Perinatal exposure
3. Good health
Breast Feeding
Perfluoroalkyl substances
Alkanesulfonic Acids
Maternal Exposure
Perfluorooctanoic acid
Female
France
[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
Caprylates
Perinatal period
Environmental Monitoring
Subjects
Details
- ISSN :
- 01604120
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Environment International
- Accession number :
- edsair.doi.dedup.....eb57e353115b7abfa1b5e86b8bc65e13