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Magnetic solid-phase extraction based on carbon nanotubes for the determination of polyether antibiotic and s-triazine drug residues in animal food with LC-MS/MS
- Source :
- Journal of separation science. 40(11)
- Publication Year :
- 2017
-
Abstract
- Carbon nanotubes-magnetic nanoparticles, comprising ferroferric oxide nanoparticles and carbon nanotubes, were prepared through a simple one-step synthesis method and subsequently applied to magnetic solid-phase extraction for the determination of polyether antibiotic and s-triazine drug residues in animal food coupled with liquid chromatography with tandem mass spectrometry. The nanocomposites were characterized by transmission electron microscopy, X-ray diffraction, and vibrating sample magnetometry. The components within the nanocomposites endowed the material with high extraction performance and manipulative convenience. Compared with carbon nanotubes, the as-prepared carbon nanotubes-magnetic nanoparticles showed better extraction and separation efficiencies for polyether antibiotics and s-triazine drugs thanks to the contribution of the iron-containing magnetic nanoparticles. Various experimental parameters affecting the extraction efficiency had been investigated in detail. Under the optimal conditions, the good linearity ranging from 1 to 200 μg/kg for diclazuril, toltrazuril, toltrazuril sulfone, lasalocid, monensin, salinomycin, narasin, nanchangmycin, and maduramicin, low limits of detection ranging from 1 to 5 μg/kg, and satisfactory spiked recoveries (77.1-91.2%, with the inter relative standard deviation values from 4.0 to 12.2%) were shown. It was confirmed that this novel method was an efficient pretreatment and enrichment procedure and could be successfully applied for extraction and determination of polyether and s-triazine drug residues in complex matrices.
- Subjects :
- Animal food
Narasin
Filtration and Separation
02 engineering and technology
Carbon nanotube
01 natural sciences
Analytical Chemistry
law.invention
chemistry.chemical_compound
law
Tandem Mass Spectrometry
Solid phase extraction
Detection limit
Chromatography
Nanotubes, Carbon
Triazines
010401 analytical chemistry
Monensin
Extraction (chemistry)
Solid Phase Extraction
021001 nanoscience & nanotechnology
Animal Feed
Drug Residues
0104 chemical sciences
Anti-Bacterial Agents
chemistry
Magnetic nanoparticles
0210 nano-technology
Chromatography, Liquid
Subjects
Details
- ISSN :
- 16159314
- Volume :
- 40
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of separation science
- Accession number :
- edsair.doi.dedup.....eb3beb3ea8ff1c8f4c5515fd4bdff6f0