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Triploidy-Observations in 154 Diandric Cases
- Source :
- Scholz, N B, Bolund, L, Nyegaard, M, Faaborg, L, Jørgensen, M W, Lund, H, Niemann, I & Sunde, L 2015, ' Triploidy-Observations in 154 Diandric Cases ', PLOS ONE, vol. 10, no. 11, pp. e0142545 . https://doi.org/10.1371/journal.pone.0142545, PLoS ONE, Vol 10, Iss 11, p e0142545 (2015), Scholz, N B, Bolund, L, Nyegaard, M, Faaborg, L, Jørgensen, M W, Lund, H, Niemann, I & Sunde, L 2015, ' Triploidy-Observations in 154 Diandric Cases ', PLOS ONE, vol. 10, no. 11, e0142545 . https://doi.org/10.1371/journal.pone.0142545, PLoS ONE
- Publication Year :
- 2015
-
Abstract
- Hydatidiform moles (HMs) are abnormal human pregnancies with vesicular chorionic villi, imposing two clinical challenges; miscarriage and a risk of gestational trophoblastic neoplasia (GTN). The parental type of most HMs are either diandric diploid (PP) or diandric triploid (PPM). We consecutively collected 154 triploid or near-triploid samples from conceptuses with vesicular chorionic villi. We used analysis of DNA markers and/or methylation sensitive-MLPA and collected data from registries and patients records. We performed whole genome SNP analysis of one case of twinning (PP+PM).In all 154 triploids or near-triploids we found two different paternal contributions to the genome (P1P2M). The ratios between the sex chromosomal constitutions XXX, XXY, and XYY were 5.7: 6.9: 1.0. No cases of GTN were observed. Our results corroborate that all triploid human conceptuses with vesicular chorionic villi have the parental type P1P2M. The sex chromosomal ratios suggest approximately equal frequencies of meiosis I and meiosis II errors with selection against the XYY conceptuses or a combination of dispermy, non-disjunction in meiosis I and meiosis II and selection against XYY conceptuses. Although single cases of GTN after a triploid HM have been reported, the results of this study combined with data from previous prospective studies estimate the risk of GTN after a triploid mole to 0% (95% CI: 0-1,4%).
- Subjects :
- Male
Genotype
Karyotype
lcsh:Medicine
Biology
Miscarriage
Andrology
Meiosis
Pregnancy
medicine
Humans
lcsh:Science
Sex Chromosome Aberrations
reproductive and urinary physiology
Genetics
Multidisciplinary
Zygote
Models, Genetic
Genome, Human
Meiosis II
lcsh:R
fungi
food and beverages
Hydatidiform Mole
medicine.disease
Diploidy
Triploidy
medicine.anatomical_structure
Karyotyping
embryonic structures
Chorionic villi
Female
lcsh:Q
Chorionic Villi
Ploidy
Research Article
SNP array
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scholz, N B, Bolund, L, Nyegaard, M, Faaborg, L, Jørgensen, M W, Lund, H, Niemann, I & Sunde, L 2015, ' Triploidy-Observations in 154 Diandric Cases ', PLOS ONE, vol. 10, no. 11, pp. e0142545 . https://doi.org/10.1371/journal.pone.0142545, PLoS ONE, Vol 10, Iss 11, p e0142545 (2015), Scholz, N B, Bolund, L, Nyegaard, M, Faaborg, L, Jørgensen, M W, Lund, H, Niemann, I & Sunde, L 2015, ' Triploidy-Observations in 154 Diandric Cases ', PLOS ONE, vol. 10, no. 11, e0142545 . https://doi.org/10.1371/journal.pone.0142545, PLoS ONE
- Accession number :
- edsair.doi.dedup.....eb3b8a6147e85a90ef100d063552689f