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Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review
- Source :
- Natural Products and Bioprospecting
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Dendrobium Sw. is one of the largest genera in the orchidaceous family and includes 900–2000 species. Among them, more than 80 Dendrobium species have been reported in China. However, there are only six Dendrobium species, namely, D. bigibbum var. superbum (syn. D. phalaenopsis), D. chrysanthum, D. fimbriatum, D. loddigesii, D. nobile, and D. officinale (syn. D. candidum), listed in the New Inventory of Existing Cosmetic Ingredients in China Launched. Artificial planting of Dendrobium species has been a great success in China. To better utilize Dendrobium resources for medicinal and cosmetic purposes, we summarize their traditional uses and pharmacologically active compounds for treating dermatological disorders in this review. “Orchidaceae”, “Dendrobium”, “traditional use”, “ethnobotany”, “dermatological disorder”, and “skin disease” were used as search terms to screen the literature. Cited references were collected between 1970 and 2020 from the Web of Science, China National Knowledge Internet (CNKI), SciFinder, Google Scholar, and Chinese books. From the search, it was found that there are 22 Dendrobium species with traditional uses in dermatological disorders, and 131 compounds from Dendrobium plants have been reported to possess anti-inflammatory, antimicrobial, antioxidant, antiaging, anti-psoriasis, and tyrosinase-inhibitory activities, implying that Dendrobium plants are important resources for the discovery of active compounds and the development of new drugs and cosmetics. D. crepidatum, D. denneanum, D. loddigesii, D. nobile, and D. officinale have been extensively studied. More research on other Dendrobium species is needed. The major active compounds found in Dendrobium species are phenanthrenes, alkaloids, flavonoids, phenylpropanoids, and lignans. Several compounds, such as loddigesiinol A, (S)-5-methoxy-2,4,7,9-tetrahydroxy-9,10-dihydrophenanthrene, (S)-4-methoxy-2,5,7,9-tetrahydroxy-9,10-dihydrophenanthrene, 2,5-dihydroxy-4-methoxy-phenanthrene 2-O-β-d-glucopyranoside, (9R)-1,2,5,9-tetrahydroxy-9,10-dihydrophenanthrene 5-O-β-d-glucopyranoside, (+)-homocrepidine A, and vicenin 2, have significant anti-inflammatory activities and inhibit nitric oxide (NO) production with IC50 values less than 5 μM, and these compounds are worthy of further study. Graphic Abstract
- Subjects :
- Dermatological disorders
Review
Plant Science
Toxicology
01 natural sciences
Biochemistry
Analytical Chemistry
Dendrobium
03 medical and health sciences
Ic50 values
Orchidaceae
030304 developmental biology
Pharmacology
0303 health sciences
Traditional uses
biology
Traditional medicine
010405 organic chemistry
Organic Chemistry
biology.organism_classification
0104 chemical sciences
Search terms
Ethnobotany
Plant biochemistry
Phalaenopsis
Anti-inflammatory
Food Science
Subjects
Details
- ISSN :
- 21922209 and 21922195
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Natural Products and Bioprospecting
- Accession number :
- edsair.doi.dedup.....eb2f126e76782ffcb8836db30c63d2f9