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Sodium-glucose cotransporter-2 inhibition and the insulin: Glucagon ratio: Unexplored dimensions
- Source :
- Indian Journal of Endocrinology and Metabolism, Vol 19, Iss 3, Pp 426-429 (2015), Indian Journal of Endocrinology and Metabolism
- Publication Year :
- 2015
- Publisher :
- Wolters Kluwer Medknow Publications, 2015.
-
Abstract
- The sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a novel class of glucose-lowering drugs which act by inhibiting the reabsorption of filtered glucose from the kidneys. Their effect on insulin and glucagon levels has recently been studied but is not fully explained. This communication proposes various hypotheses: A direct effect of SGLT-2 inhibition on the alpha cell receptors, a paracrine or intra-islet mediated effect on alpha cell sensitivity to glucose, and a calorie restriction mimetic action, to explain the impact of these drugs on the insulin glucagon ratio.
- Subjects :
- medicine.medical_specialty
insulin
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Calorie restriction
empagliflozin
Brief Communication
Glucagon
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Alpha cell
Endocrinology
Internal medicine
Medicine
lcsh:RC799-869
canagliflozin
lcsh:RC648-665
diabetes
business.industry
Reabsorption
Insulin
dapagliflozin
Beta cell
glucagon
Sodium/Glucose Cotransporter 2
lcsh:Diseases of the digestive system. Gastroenterology
business
Cotransporter
Subjects
Details
- Language :
- English
- ISSN :
- 22309500 and 22308210
- Volume :
- 19
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....eb12535e8338270bd18187591bfe2b95