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Circulating CD34-Positive Cell Number Is Associated With Brain Natriuretic Peptide Level in Type 2 Diabetic Patients
- Source :
- Diabetes Care. 31:157-158
- Publication Year :
- 2008
- Publisher :
- American Diabetes Association, 2008.
-
Abstract
- Patients with type 2 diabetes often suffer from asymptomatic left ventricular (LV) injury, including increased LV mass, without apparent myocardial ischemia. The mechanisms underlying diabetic LV injury remain unclear; however, it has been suggested that endothelial dysfunction plays a role. Accumulating evidence indicates that bone marrow–derived endothelial progenitor cells (EPCs) contribute to neovascularization of ischemic tissue and endothelialization of denuded endothelium. Recent studies have shown that circulating bone marrow–derived immature cells, including CD34+ cells, contribute to the maintenance of the vasculature, both as a pool of EPCs and as the source of growth/angiogenesis factors (1). We hypothesized that circulating CD34+ cells might be associated with LV dysfunction in patients with type 2 diabetes. Therefore, we studied the correlation between circulating CD34+ cell levels and plasma brain natriuretic peptide (BNP) levels, an LV dysfunction marker, in type 2 diabetic patients. The institutional review board of the National Cardiovascular Center approved this study, and all subjects provided informed consent. We examined 26 patients with type 2 diabetes (12 men and 14 women, duration of diabetes 16.1 ± 10.7 years) who were over 60 years of age (70.5 ± 6.4 years). Statin was given to nine subjects. ACE inhibitor or angiotensin receptor blocker was given to nine subjects, and thiazolidinedione was given to two subjects. Subjects were excluded from the study if they had known cardiovascular disease or chronic renal failure (defined as serum creatinine ≥180 μmol/l). No study subject showed hypokinesis by echocardiography or electrocardiogram change, indicating myocardial ischemia. …
- Subjects :
- Male
medicine.medical_specialty
Statin
Endothelium
medicine.drug_class
Angiogenesis
Endocrinology, Diabetes and Metabolism
Antigens, CD34
Blood Pressure
Cell Count
Type 2 diabetes
Diabetes mellitus
Internal medicine
Natriuretic Peptide, Brain
Internal Medicine
medicine
Humans
Endothelial dysfunction
Aged
Advanced and Specialized Nursing
business.industry
Middle Aged
medicine.disease
Brain natriuretic peptide
Endocrinology
medicine.anatomical_structure
Diabetes Mellitus, Type 2
ACE inhibitor
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....eb07c68b391d4f4423f40d06fbdc1a27