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A rare cause of coagulopathy in a patient with rapidly progressive renal failure

Authors :
Manish Rathi
Jasmine Sethi
Pankaj Malhotra
Rudreshwar Prabakaran
Krishan Lal Gupta
Harbir Singh Kohli
Source :
Indian Journal of Nephrology, Vol 30, Iss 2, Pp 110-112 (2020), Indian Journal of Nephrology
Publication Year :
2020
Publisher :
Wolters Kluwer Medknow Publications, 2020.

Abstract

Deranged coagulogram is a common problem, which a nephrologist faces before doing a renal biopsy. We describe a rare cause of coagulopathy in a patient with rapidly progressive renal failure due to acquired factor X deficiency caused by systemic light chain amyloidosis (AL). The patient had prolonged prothrombin and activated partial thromboplastin time, which got corrected on mixing with normal plasma, and factor X activity was markedly reduced at 5%. Rectal biopsy and immunofixation electrophoresis established the diagnosis of AL and the patient was started on bortezomib-based chemotherapy. Hence, appropriate coagulation work-up should be conducted in patients with renal dysfunction with prolonged coagulation times, as it can sometimes reveal the underlying diagnosis in situations where renal biopsy could not be done due to high risk of bleeding.

Details

Language :
English
ISSN :
19983662 and 09714065
Volume :
30
Issue :
2
Database :
OpenAIRE
Journal :
Indian Journal of Nephrology
Accession number :
edsair.doi.dedup.....eaf7a214e7e125bb779da2096570a652