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A rare cause of coagulopathy in a patient with rapidly progressive renal failure
- Source :
- Indian Journal of Nephrology, Vol 30, Iss 2, Pp 110-112 (2020), Indian Journal of Nephrology
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer Medknow Publications, 2020.
-
Abstract
- Deranged coagulogram is a common problem, which a nephrologist faces before doing a renal biopsy. We describe a rare cause of coagulopathy in a patient with rapidly progressive renal failure due to acquired factor X deficiency caused by systemic light chain amyloidosis (AL). The patient had prolonged prothrombin and activated partial thromboplastin time, which got corrected on mixing with normal plasma, and factor X activity was markedly reduced at 5%. Rectal biopsy and immunofixation electrophoresis established the diagnosis of AL and the patient was started on bortezomib-based chemotherapy. Hence, appropriate coagulation work-up should be conducted in patients with renal dysfunction with prolonged coagulation times, as it can sometimes reveal the underlying diagnosis in situations where renal biopsy could not be done due to high risk of bleeding.
- Subjects :
- Nephrology
medicine.medical_specialty
Chemotherapy
medicine.diagnostic_test
business.industry
Bortezomib
medicine.medical_treatment
Amyloidosis
light chain amyloidosis
Case Report
factor x deficiency
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
lcsh:RC870-923
Gastroenterology
coagulopathy
Coagulation
Internal medicine
Coagulopathy
medicine
Renal biopsy
business
medicine.drug
Partial thromboplastin time
Subjects
Details
- Language :
- English
- ISSN :
- 19983662 and 09714065
- Volume :
- 30
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....eaf7a214e7e125bb779da2096570a652