Back to Search
Start Over
Effect of HMG-CoA reductase inhibitors on vascular cell apoptosis: Beneficial or detrimental?
- Source :
- Atherosclerosis. 211:9-14
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Vascular cell apoptosis, an active form of programmed cell death, plays an integral role in atherosclerosis and in-stent restenosis after angioplasty, thus promoting the precipitation of acute cardiovascular events. Beyond their cholesterol-lowering effects, HMG-CoA reductase inhibitors, or statins, have been persistently reported to influence the apoptotic process. In this review we discuss the effect of statin treatment on vascular cell apoptosis, and therefore on atherosclerosis development, plaque rupture and in-stent restenosis, based on the results of up-to-date experimental and clinical studies. Lipophilic statins have been shown to induce apoptosis in a variety of cell types, including vascular smooth muscle cells and endothelial cells, whereas hydrophilic statins (rosuvastatin and pravastatin) have not. The clinical importance of statin induced apoptosis remains controversial, as it may blunt vascular wall thickening in the early stages of atherosclerosis or reduce the neointimal response to injury on the one hand, but on the other hand it may also promote destabilization of vulnerable plaques precipitating acute cardiovascular events. Current data support the initiation of statin treatment early enough to inhibit both the formation of atherosclerotic plaques (primary prevention) and in-stent restenosis (secondary prevention). Atherosclerosis
- Subjects :
- Programmed cell death
medicine.medical_specialty
Statin
Vascular smooth muscle
medicine.drug_class
Apoptosis
Restenosis
Internal medicine
Humans
Medicine
Rosuvastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/therapeutic use
cardiovascular diseases
Graft Occlusion, Vascular/prevention & control
biology
business.industry
Vascular disease
Graft Occlusion, Vascular
nutritional and metabolic diseases
Apoptosis/*drug effects
Atherosclerosis
medicine.disease
Endocrinology
Atherosclerosis/pathology/*prevention & control
HMG-CoA reductase
Cancer research
biology.protein
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Pravastatin
medicine.drug
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....eae35d131f2daf256fc4bfa839d72249