Back to Search
Start Over
Dynamic chromosome movements during meiosis: a way to eliminate unwanted connections?
- Source :
- Trends in Cell Biology, Trends in Cell Biology, 2009, 19 (12), pp.716-724. ⟨10.1016/j.tcb.2009.09.007⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; Dramatic chromosome motion is a characteristic of mid-prophase of meiosis that is observed across broadly divergent eukaryotic phyla. Although the specific mechanisms underlying chromosome motions vary among organisms studied to date, the outcome is similar in all cases: vigorous back-and-forth movement (as fast as approximately 1mum/sec for budding yeast), led by chromosome ends (or near-end regions), and directed by cytoskeletal components via direct association through the nuclear envelope. The exact role(s) of these movements remains unknown, although an idea gaining currency is that movement serves as a stringency factor, eliminating unwanted inter-chromosomal associations or entanglements that have arisen as part of the homolog pairing process and, potentially, unwanted associations of chromatin with the nuclear envelope. Turbulent chromosome movements observed during bipolar orientation of chromosomes for segregation could also serve similar roles during mitosis. Recent advances shed light on the contribution of protein complexes involved in the meiotic movements in chromosome dynamics during the mitotic program.
- Subjects :
- MESH: Cell Nucleus
Condensin
Biology
Chromosomes
Article
03 medical and health sciences
0302 clinical medicine
Meiosis
medicine
MESH: Cytoskeleton
Animals
Humans
MESH: Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Cytoskeleton
Mitosis
030304 developmental biology
Cell Nucleus
Genetics
0303 health sciences
MESH: Humans
Chromosome
Cell Biology
Budding yeast
Chromatin
Cell nucleus
MESH: Meiosis
medicine.anatomical_structure
Evolutionary biology
biology.protein
MESH: Chromosomes
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 09628924
- Database :
- OpenAIRE
- Journal :
- Trends in Cell Biology, Trends in Cell Biology, 2009, 19 (12), pp.716-724. ⟨10.1016/j.tcb.2009.09.007⟩
- Accession number :
- edsair.doi.dedup.....eae0a49ac154d936a94443ff411a02fc