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Lower Frequency of CD62Lhighand Higher Frequency of TNFR2+Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients
- Source :
- Mediators of Inflammation, Vol 2011 (2011), Mediators of Inflammation
- Publication Year :
- 2011
- Publisher :
- Hindawi Limited, 2011.
-
Abstract
- Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autoreactive T cells. CD62L is a surface molecule that plays role in homing capabilities of Tregs, and only cells with high expression of CD62L have high suppressive potential. Tregs are also characterized by the constant expression of TNFR2. The frequency of Tregs carrying TNFR2 is higher in inflammatory conditions. We investigated blood regulatory T cells with CD62L expression and regulatory T cells expressing TNFR2 in type 1 diabetic patients. We found differences in these populations when comparing to healthy individuals. We propose that these may be associated with inflammatory conditions that are present in patients with type 1 diabetes. The lower percentage of Tregs and Treg CD62Lhighmay contribute to ineffective suppression of proinflammatory cytokines production during type 1 diabetes.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
Article Subject
Adolescent
Immunology
Enzyme-Linked Immunosorbent Assay
chemical and pharmacologic phenomena
medicine.disease_cause
T-Lymphocytes, Regulatory
Proinflammatory cytokine
Autoimmunity
Young Adult
Diabetes mellitus
lcsh:Pathology
medicine
Humans
Receptors, Tumor Necrosis Factor, Type II
L-Selectin
Autoimmune disease
Type 1 diabetes
biology
Tumor Necrosis Factor-alpha
Interleukin-2 Receptor alpha Subunit
hemic and immune systems
Cell Biology
Flow Cytometry
medicine.disease
Diabetes Mellitus, Type 1
biology.protein
Female
L-selectin
Tumor necrosis factor alpha
Research Article
lcsh:RB1-214
Homing (hematopoietic)
Subjects
Details
- ISSN :
- 14661861 and 09629351
- Volume :
- 2011
- Database :
- OpenAIRE
- Journal :
- Mediators of Inflammation
- Accession number :
- edsair.doi.dedup.....eacf2aefb6779318e7c608237c854f06
- Full Text :
- https://doi.org/10.1155/2011/645643