Back to Search
Start Over
Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease
- Source :
- Molecular and cellular biochemistry. 325(1-2)
- Publication Year :
- 2008
-
Abstract
- Background The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD). Methods The study included 235 patients with CAD and 268 healthy control subjects. Results LL and LM genotypes and L allele of PON1 55 were over-represented in patients. In contrast, MM genotype and M allele were more frequent in controls. QQ genotype and Q allele of PON1 192 and CT genotype of MTHFR were significantly diminished and QR genotype and R allele were significantly elevated in CAD patients compared with controls. The plasma tHcy were elevated but B12 levels were diminished in patients. PON1 55 and 192 genetic variants were significantly associated with PON1 activity, triglyceride, total cholesterol, tHcy and, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol in patients, respectively. Conclusion Genetic variants of PON1 55/192 and MTHFR were associated with CAD.
- Subjects :
- Male
medicine.medical_specialty
Homocysteine
Clinical Biochemistry
Coronary Artery Disease
chemistry.chemical_compound
Folic Acid
Internal medicine
Genotype
medicine
Humans
Vitamin B12
Cyanocobalamin
Allele
Molecular Biology
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
Genetics
biology
business.industry
Aryldialkylphosphatase
Paraoxonase
Cell Biology
General Medicine
Middle Aged
PON1
Vitamin B 12
Endocrinology
chemistry
Methylenetetrahydrofolate reductase
biology.protein
Female
business
Subjects
Details
- ISSN :
- 15734919
- Volume :
- 325
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Molecular and cellular biochemistry
- Accession number :
- edsair.doi.dedup.....eabf701bd2978c52d7777bf691d5ad59