Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

Authors :: Jortan O. Tun
Noel M. Lacerna
Eric W. Schmidt
Cydee Marie V. Ramones
Lilibeth A. Salvador-Reyes
Margo G. Haygood
Jose Miguel D. Robes
Myra Ruth D. Picart
Gisela P. Concepcion
Bailey W. Miller
Source :: Marine Drugs, Volume 18, Issue 12, Marine Drugs, Vol 18, Iss 656, p 656 (2020)
Publication Year :: 2020
Publisher :: MDPI AG, 2020.
Abstract: The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2&ndash<br />3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1&ndash<br />3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1&ndash<br />3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.

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