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Characterization of selective antibacterial peptides by polarity index
- Source :
- International Journal of Peptides
- Publication Year :
- 2011
-
Abstract
- In the recent decades, antibacterial peptides have occupied a strategic position for pharmaceutical drug applications and became subject of intense research activities since they are used to strengthen the immune system of all living organisms by protecting them from pathogenic bacteria. This work proposes a simple and easy statistical/computational method through a peptide polarity index measure by which an antibacterial peptide subgroup can be efficiently identified, that is, characterized by a high toxicity to bacterial membranes but presents a low toxicity to mammal cells. These peptides also have the feature not to adopt to an alpha-helicoidal structure in aqueous solution. The double-blind test carried out to the whole Antimicrobial Peptide Database (November 2011) showed an accuracy of 90% applying the polarity index method for the identification of such antibacterial peptide groups.
- Subjects :
- chemistry.chemical_classification
Pharmaceutical drug
Article Subject
Polarity (physics)
medicine.medical_treatment
Peptide
Pathogenic bacteria
Biology
medicine.disease_cause
Antimicrobial
Bioinformatics
Biochemistry
Antibacterial peptide
Immune system
Membrane
chemistry
medicine
Research Article
Subjects
Details
- ISSN :
- 16879775
- Volume :
- 2012
- Database :
- OpenAIRE
- Journal :
- International journal of peptides
- Accession number :
- edsair.doi.dedup.....ea981507bcf2d1bcc1d698f516f096b7