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Dietary Soluble Fiber Lowers Plasma LDL Cholesterol Concentrations by Altering Lipoprotein Metabolism in Female Guinea Pigs
- Source :
- The Journal of Nutrition. 128:1434-1441
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- This experiment was designed to evaluate the effects of pectin (PE), guar gum (GG) and psyllium (PSY) intake on VLDL and LDL metabolism in female guinea pigs fed high dietary cholesterol. Guinea pigs were fed a 15 g/100 g fat diet containing 0.25 g/100 g cholesterol with 12.5 g/100 g PE, 12.5 g/100 g GG, 7.5 g/100 g PSY or 12.5 g/100 g cellulose (control diet) for 4 wk. Plasma cholesterol concentrations were 29, 43 and 39% lower in guinea pigs fed PE, GG or PSY, respectively, compared with the control group (P < 0.0001). Plasma apolipoprotein (apo) B concentrations were 16-22% lower in the groups fed soluble fiber compared with the control group (P < 0.01). In contrast, hepatic cholesterol and triglyceride concentrations were not different among the PE, GG, PSY and control groups. No differences in triacylglycerol (TAG) or apo B secretion rates, measured by blocking VLDL catabolism by triton (WR 1339) injection, were observed, whereas plasma LDL apo B fractional catabolic rates (FCR), determined by injection of radiolabeled LDL, were higher in guinea pigs fed GG or PSY than in those from the control group. All sources of dietary soluble fiber reduced LDL apo B flux (P < 0.05). These results suggest that the mechanisms of plasma LDL cholesterol lowering by dietary soluble fiber are distinctive for each fiber source and result in specific alterations in lipoprotein metabolism in female guinea pigs. Differences between male and female guinea pigs in response to these diets are discussed.
- Subjects :
- Dietary Fiber
Male
medicine.medical_specialty
Very low-density lipoprotein
Apolipoprotein B
Lipoproteins
Guinea Pigs
Medicine (miscellaneous)
Caviidae
Lipoproteins, VLDL
Biology
Galactans
Psyllium
Mannans
Guinea pig
chemistry.chemical_compound
Sex Factors
Internal medicine
Plant Gums
Blood plasma
medicine
Animals
Triglycerides
Apolipoproteins B
Nutrition and Dietetics
Triglyceride
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
biology.organism_classification
Endocrinology
chemistry
Microsomes, Liver
biology.protein
Pectins
Female
lipids (amino acids, peptides, and proteins)
Lipoprotein
Subjects
Details
- ISSN :
- 00223166
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- The Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....ea965d0c2cb871a6e422799c47c1da14