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Comparison of alfuzosin 10 mg with or without propiverine 10 mg, 20 mg in men with lower urinary tract symptom and an overactive bladder: randomised, single-blind, prospective study
- Source :
- International Journal of Clinical Practice. 68:471-477
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Summary Purpose The efficacy and safety of treatment with alfuzosin 10 mg plus propiverine 10 or 20 mg in men with lower urinary tract symptoms (LUTS) and an overactive bladder were investigated. Materials and methods In this parallel-arm, prospective, multicentre, single-blind study, men who were ≥ 40 years old, had an International Prostate Symptom Score (IPSS) of ≥ 8, an Overactive Bladder Symptom Score (OABSS) of ≥ 3 and an OABSS urgency item score of ≥ 2 were randomised in a 1 : 1 :1 ratio to receive alfuzosin 10 mg alone (Group A) or with propiverine 10 mg (Group B) or 20 mg (Group C) for 8 weeks. Four and 8 weeks after commencing treatment, OABSS was measured along with IPSS, maximal urinary flow rate (Qmax) and postvoid residual volume (PVR). Adverse events were recorded. Results A total of 135 men, including 43 in Group A, 48 in Group B and 44 in Group C, completed the study. Relative to baseline, all groups demonstrated significant reductions in OABSS and the IPSS after eight treatment weeks (p
- Subjects :
- Male
medicine.medical_specialty
Urinary system
Urology
Benzilates
Lower Urinary Tract Symptoms
Lower urinary tract symptoms
Statistical significance
medicine
Humans
Single-Blind Method
Prospective Studies
Prospective cohort study
Alfuzosin
Urinary Bladder, Overactive
business.industry
General Medicine
Middle Aged
medicine.disease
Treatment Outcome
Overactive bladder
Anesthesia
Quinazolines
Urological Agents
Drug Therapy, Combination
Propiverine
International Prostate Symptom Score
business
medicine.drug
Subjects
Details
- ISSN :
- 13685031
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Practice
- Accession number :
- edsair.doi.dedup.....ea922d5b953904f31ed02fdd83fddc44