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Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries
- Source :
- Ok, C Y, Li, L, Xu-Monette, Z Y, Visco, C, Tzankov, A, Manyam, G C, Montes-Moreno, S, Dybkær, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Chen, J, Richards, K L, Hsi, E D, Choi, W W L, van Krieken, J H, Huh, J, Ai, W, Ponzoni, M, Ferreri, A J M, Farnen, J P, Møller, M B, Bueso-Ramos, C E, Miranda, R N, Winter, J N, Piris, M A, Medeiros, L J & Young, K H 2014, ' Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries ', Clinical Cancer Research, vol. 20, no. 9, pp. 2338-2349 . https://doi.org/10.1158/1078-0432.CCR-13-3157, Clinical Cancer Research, 20, 2338-2349, Clinical Cancer Research, 20, 9, pp. 2338-2349, Ok, C Y, Li, L, Xu-Monette, Z Y, Visco, C, Tzankov, A, Manyam, G C, Montes-Moreno, S, Dybkaer, K, Dybaer, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Chen, J, Richards, K L, Hsi, E D, Choi, W W L, van Krieken, J H, Huh, J, Ai, W, Ponzoni, M, Ferreri, A J M, Farnen, J P, Møller, M B, Bueso-Ramos, C E, Miranda, R N, Winter, J N, Piris, M A, Medeiros, L J & Young, K H 2014, ' Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries ', Clinical Cancer Research, vol. 20, no. 9, pp. 2338-2349 . https://doi.org/10.1158/1078-0432.CCR-13-3157
- Publication Year :
- 2014
-
Abstract
- Purpose: Epstein–Barr virus–positive (EBV+) diffuse large B-cell lymphoma (DLBCL) of the elderly is a variant of DLBCL with worse outcome that occurs most often in East-Asian countries and is uncommon in the Western hemisphere. We studied the largest cohort of EBV+ DLBCL, independent of age, treated with rituximab combined with CHOP (R-CHOP) in developed Western countries. Experimental design: A large cohort (n = 732) of patients with DLBCL treated with R-CHOP chemotherapy is included from the multicenter consortium. This study group has been studied for expression of different biomarkers by immunohistochemistry, genetic abnormalities by FISH and mutation analysis, genomic information by gene expression profiling (GEP), and gene set enrichment analysis (GSEA). Results: Twenty-eight patients (4.0%) were positive for EBV with a median age of 60.5 years. No clinical characteristics distinguished patients with EBV+ DLBCL from patients with EBV-negative (EBV−) DLBCL. Genetic aberrations were rarely seen. NF-κB p50, phosphorylated STAT-3, and CD30 were more commonly expressed in EBV+ DLBCLs (P < 0.05). Significant differences in survival were not observed in patients with EBV+ DLBCL versus EBV− DLBCL. However, CD30 expression combined with EBV conferred an inferior outcome. GEP showed a unique expression signature in EBV+ DLBCL. GSEA revealed enhanced activity of the NF-κB and JAK/STAT pathways independent of molecular subtype. Conclusions: The clinical characteristics of patients with EBV+ versus EBV− DLBCL are similar and EBV infection does not predict a worse outcome. EBV+ DLBCL, however, has a unique genetic signature. CD30 expression is more common in EBV+ DLBCL and, consistent CD30 and EBV is associated with an adverse outcome. Clin Cancer Res; 20(9); 2338–49. ©2014 AACR.
- Subjects :
- Male
Cancer Research
Epstein-Barr Virus Infections
CD30
Lymphoma
Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]
CHOP
Antibodies, Monoclonal, Murine-Derived
immune system diseases
hemic and lymphatic diseases
Monoclonal
Antineoplastic Combined Chemotherapy Protocols
Prevalence
Cluster Analysis
Phosphorylation
Adult
Aged
Cyclophosphamide
Developed Countries
Doxorubicin
Female
Gene Expression Profiling
Humans
Ki-1 Antigen
Lymphoma, Large B-Cell, Diffuse
Middle Aged
NF-kappa B
Neoplasm Staging
Prednisone
Survival Analysis
Treatment Outcome
Tumor Burden
Vincristine
Diffuse
Oncology
Rituximab
medicine.drug
Murine-Derived
Biology
Article
Antibodies
medicine
Large B-Cell
Epstein–Barr virus infection
neoplasms
Survival analysis
Cancer
medicine.disease
Immunology
Cancer research
Diffuse large B-cell lymphoma
Subjects
Details
- Language :
- English
- ISSN :
- 10780432
- Database :
- OpenAIRE
- Journal :
- Ok, C Y, Li, L, Xu-Monette, Z Y, Visco, C, Tzankov, A, Manyam, G C, Montes-Moreno, S, Dybkær, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Chen, J, Richards, K L, Hsi, E D, Choi, W W L, van Krieken, J H, Huh, J, Ai, W, Ponzoni, M, Ferreri, A J M, Farnen, J P, Møller, M B, Bueso-Ramos, C E, Miranda, R N, Winter, J N, Piris, M A, Medeiros, L J & Young, K H 2014, ' Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries ', Clinical Cancer Research, vol. 20, no. 9, pp. 2338-2349 . https://doi.org/10.1158/1078-0432.CCR-13-3157, Clinical Cancer Research, 20, 2338-2349, Clinical Cancer Research, 20, 9, pp. 2338-2349, Ok, C Y, Li, L, Xu-Monette, Z Y, Visco, C, Tzankov, A, Manyam, G C, Montes-Moreno, S, Dybkaer, K, Dybaer, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Chen, J, Richards, K L, Hsi, E D, Choi, W W L, van Krieken, J H, Huh, J, Ai, W, Ponzoni, M, Ferreri, A J M, Farnen, J P, Møller, M B, Bueso-Ramos, C E, Miranda, R N, Winter, J N, Piris, M A, Medeiros, L J & Young, K H 2014, ' Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries ', Clinical Cancer Research, vol. 20, no. 9, pp. 2338-2349 . https://doi.org/10.1158/1078-0432.CCR-13-3157
- Accession number :
- edsair.doi.dedup.....ea8edd9c85de59123b2eb0e78f2c4c46
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-13-3157