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Association of P2RX7 functional variants with localized aggressive periodontitis
- Source :
- J Periodontal Res
- Publication Year :
- 2019
-
Abstract
- OBJECTIVE: The purpose of this study was to investigate involvement of the P2X7 receptor in the rare condition, localized aggressive periodontitis. MATERIAL AND METHODS: Peripheral blood from 220 African-Americans (103 with localized aggressive periodontitis and 117 healthy unrelated controls) was stimulated with lipopolysaccharide from E.coli and Porphyromonas gingivalis. P2RX7 single nucleotide polymorphisms rs208294 (H155Y), rs1718119 (T348A), rs2230911 (T357S), and rs3751143 (E496A) were genotyped in 103 localized aggressive periodontitis patients and 117 healthy unrelated subjects. We examined genetic association between four P2RX7 single nucleotide polymorphisms and localized aggressive periodontitis, and tested for correlations between the single nucleotide polymorphisms and inflammatory response to lipopolysaccharide in blood samples from these patients. RESULTS: A significant association with localized aggressive periodontitis was observed with rs1718119 A (Thr) allele (p=0.0063, odds ratio = 1.904), and with a haplotype containing this allele (p=0.0075). Additionally, significant correlations with these data were found: the rs1718119 G allele correlated with greater production of IL-6, IL-2, and GM-CSF; the C (His) allele of rs208294 correlated with lower levels of IL-12p40; and the C (Thr) allele of rs2230911 correlated with greater levels of G-CSF. CONCLUSIONS: The data from these analyses support a possible biological relationship between P2RX7 genetic variants and inflammatory response in localized aggressive periodontitis patients.
- Subjects :
- 0301 basic medicine
Male
Adolescent
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Aggressive periodontitis
Humans
Allele
Child
Porphyromonas gingivalis
Gene
Genetic Association Studies
Genetic association
biology
business.industry
Haplotype
030206 dentistry
P2RX7
biology.organism_classification
medicine.disease
Black or African American
030104 developmental biology
Aggressive Periodontitis
Haplotypes
Case-Control Studies
Immunology
Periodontics
Cytokines
Female
Receptors, Purinergic P2X7
business
Subjects
Details
- ISSN :
- 16000765
- Volume :
- 55
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of periodontal research
- Accession number :
- edsair.doi.dedup.....ea8e79c9fc67ee0a6f45b78be6875dd8