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Potential Impact of Quercetin and Idebenone against Immuno- inflammatory and Oxidative Renal Damage Induced in Rats by Titanium Dioxide Nanoparticles Toxicity
- Source :
- Journal of Oleo Science. 62:961-971
- Publication Year :
- 2013
- Publisher :
- Japan Oil Chemists' Society, 2013.
-
Abstract
- The aim of this study was to investigate the toxic impacts of titanium dioxide nanoparticles (TiO₂-NPs) on rat kidneys and the possible prophylactic role of either quercetin or idebenone. TiO₂-NPs were administered orally at either 600 mg or 1 g/kg body weight for 5 consecutive days to evaluate dose-dependent toxicity referred to the OECD guidelines for testing of chemicals. The results showed that administration of either low or high repeated doses of TiO₂-NPs to rats significantly increases serum kideney function biomarkers (urea, creatinine and uric acid) as well as increases in serum glucose and serum immuno- inflammatory biomarkers including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), immunoglobin g (IGg), vascular endothelial growth factor (VEGF, angiogenic factor) and nitric oxide (NO) with a concomitant decrease in renal GSH content versus normal control values. The increase in these biomarkers was more evident in rats intoxicated with high TiO₂-NPs repeated doses. Oral co- administration of either quercetin or idebenone (each 200mg/Kg body weight) daily for three weeks to rats intoxicated by either of the two doses markedly ameliorated TiO₂-NPs induced alteration in the above biomarkers. The prophylactic impacts of both agents on biochemical markers were more pronounced in rats received low TiO₂-NPs repeated doses. The biochemical investigation was supported by histological examination. In conclusion, The data showed the severity in renotoxicity of TiO₂-NPs was dose-dependent and the protective effect of quercetin and idebenone may be related to their antioxidant and anti-inflammatory properties.
- Subjects :
- Blood Glucose
Male
Antioxidant
Ubiquinone
General Chemical Engineering
medicine.medical_treatment
Anti-Inflammatory Agents
Administration, Oral
Metal Nanoparticles
Pharmacology
Antioxidants
Nitric oxide
chemistry.chemical_compound
medicine
Animals
Urea
Idebenone
Particle Size
Titanium
Creatinine
Dose-Response Relationship, Drug
business.industry
General Medicine
General Chemistry
Rats
Dose–response relationship
chemistry
Biochemistry
Toxicity
Cytokines
Uric acid
Kidney Diseases
Quercetin
Inflammation Mediators
business
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 13473352 and 13458957
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Journal of Oleo Science
- Accession number :
- edsair.doi.dedup.....ea8a9d30d3d808556605c73f2d5a899c