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Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients
- Source :
- Kidney international. 84(1)
- Publication Year :
- 2012
-
Abstract
- Previous studies have shown that nonsteroidal anti-inflammatory drug (NSAID) use might be associated with a lower risk of developing cancer in the general population. Patients on dialysis have increased risk for cancer, but there are no studies to determine the relationship between NSAID use and cancer risk in these patients. To identify any association between NSAID use and cancer risk in patients with end-stage renal disease on dialysis, we used Taiwan's National Health Insurance database to conduct a nationwide population-based, propensity score–matched cohort study. All cancers between groups were compared by Cox proportional hazards models. Compared to nonuse of NSAIDs, the use of non-COX-2-selective inhibitors (hazard ratio 0.81, 95% confidence interval 0.67–0.97) or COX-2-selective inhibitors (0.78, 0.62–0.98) was associated with a lower risk of developing cancer. NSAID use reduced the risk of respiratory (0.39, 0.19–0.79), breast (0.41, 0.19–0.89), kidney (0.58, 0.38–0.88), digestive tract (0.64, 0.49–0.85), and bladder cancers (0.73, 0.55–0.96). NSAID use, however, significantly increased risk for upper gastrointestinal bleeding (odds ratio, 1.15, 1.07–1.23) but not adverse cardiac or cerebrovascular events. Thus, NSAID use was associated with a lower risk of developing cancer in chronic dialysis patients; however, they should still be used with caution due to the side effects of gastrointestinal bleeding.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Databases, Factual
medicine.medical_treatment
Population
Taiwan
Lower risk
Renal Dialysis
Risk Factors
Internal medicine
Neoplasms
medicine
Odds Ratio
Humans
Renal replacement therapy
Registries
education
Propensity Score
Dialysis
Aged
Proportional Hazards Models
education.field_of_study
business.industry
Hazard ratio
Anti-Inflammatory Agents, Non-Steroidal
Cancer
Odds ratio
Middle Aged
medicine.disease
Surgery
Logistic Models
Nephrology
Multivariate Analysis
Kidney Failure, Chronic
Female
Upper gastrointestinal bleeding
business
Gastrointestinal Hemorrhage
Subjects
Details
- ISSN :
- 15231755
- Volume :
- 84
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Kidney international
- Accession number :
- edsair.doi.dedup.....ea8817e2581a0a0ba03689c9b56a39d0