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Evolutionary optimization of speed and accuracy of decoding on the ribosome
- Source :
- Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
- Publication Year :
- 2011
- Publisher :
- The Royal Society, 2011.
-
Abstract
- Speed and accuracy of protein synthesis are fundamental parameters for the fitness of living cells, the quality control of translation, and the evolution of ribosomes. The ribosome developed complex mechanisms that allow for a uniform recognition and selection of any cognate aminoacyl-tRNA (aa-tRNA) and discrimination against any near-cognate aa-tRNA, regardless of the nature or position of the mismatch. This review describes the principles of the selection—kinetic partitioning and induced fit—and discusses the relationship between speed and accuracy of decoding, with a focus on bacterial translation. The translational machinery apparently has evolved towards high speed of translation at the cost of fidelity.
- Subjects :
- Time Factors
media_common.quotation_subject
Fidelity
Peptide Elongation Factor Tu
RNA, Transfer, Amino Acyl
Biology
Ribosome
General Biochemistry, Genetics and Molecular Biology
GTP Phosphohydrolases
Evolution, Molecular
Bacterial Proteins
Position (vector)
Catalytic Domain
Prokaryotic translation
Escherichia coli
Codon
Selection (genetic algorithm)
media_common
Genetics
Hydrolysis
Translation (biology)
Articles
Enzyme Activation
Kinetics
Protein Biosynthesis
Transfer RNA
Guanosine Triphosphate
Peptides
General Agricultural and Biological Sciences
Ribosomes
Algorithm
Decoding methods
Subjects
Details
- ISSN :
- 14712970 and 09628436
- Volume :
- 366
- Database :
- OpenAIRE
- Journal :
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Accession number :
- edsair.doi.dedup.....ea85b438c8187618ea2bb378f79d79d5