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Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Study of Japanese Registry Data
- Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 24(8)
- Publication Year :
- 2017
-
Abstract
- Autologous stem cell transplantation (ASCT) is a treatment option for HIV-positive patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). However, the prognosis after ASCT in HIV-positive Japanese patients remains unclear. The aim of this study was to evaluate the impact of HIV infection on transplant outcomes after ASCT in Japan. Using the national database of the Japan Society for Hematopoietic Cell Transplantation, we retrospectively evaluated patients with NHL (n = 3862) and MM (n = 2670) who underwent their first ASCT between 2001 and 2014. The presence of HIV antibody was used to diagnose HIV infection. Fifty-six patients with NHL (1.4%) and 23 with MM (.8%) were positive for HIV antibody. Among patients with NHL overall survival (OS) was lower in HIV-positive patients than in HIV-negative patients (5-year OS: HIV-positive patients, 44% versus HIV-negative patients, 65%; P .001). In a multivariate analysis HIV infection was significantly associated with an increased risk of overall mortality (hazard ratio, 2.30; P .001). The incidence of relapse was higher in HIV-positive patients (P = .036), whereas there was a similar incidence of nonrelapse mortality (P = .879). OS in patients with MM was similar between those with/without HIV infection (5-year OS: HIV-positive patients, 61% versus HIV-negative patients, 63%; P = .988). HIV infection was associated with a higher risk of overall mortality and relapse after ASCT for NHL in a Japanese population.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Transplantation, Autologous
03 medical and health sciences
0302 clinical medicine
Autologous stem-cell transplantation
Japan
immune system diseases
hemic and lymphatic diseases
Internal medicine
Medicine
Autologous transplantation
Humans
Registries
Multiple myeloma
Aged
Retrospective Studies
Transplantation
Peripheral Blood Stem Cell Transplantation
biology
business.industry
Lymphoma, Non-Hodgkin
virus diseases
Retrospective cohort study
Hematology
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Lymphoma
030220 oncology & carcinogenesis
biology.protein
Female
Antibody
business
Multiple Myeloma
030215 immunology
Subjects
Details
- ISSN :
- 15236536
- Volume :
- 24
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....ea812cba74682323d11c9c7f8ffbd69f